RPS19-CEACAM5 Fusion FISH Probe
The RPS19-CEACAM5 Fusion FISH Probe is used to confirm a fusion of the RPS19 and CEACAM5 genes. The fusion of the RPS19 and CEACAM5 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPS19-CEACAM5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-RERE | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-REOR | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-REGO | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-REGR | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-REAQ | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-ORRE | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-OROR | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-ORGO | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-GORE | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-GOOR | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-GOGO | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-GOGR | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-GRRE | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-GROR | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-GRGO | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-GRGR | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-AQRE | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-AQOR | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-AQGO | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-AQGR | 20 (40 μL) | 200 μL |
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| RPS19-CEACAM5-20-AQAQ | 20 (40 μL) | 200 μL |
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CEACAM5 Gene Summary
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Gene Name: Carcinoembryonic Antigen Related Cell Adhesion Molecule 5
Chromosome: CHR19: 42212529 -42234437
Locus: 19q13.2
RPS19 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal Protein S19
Chromosome: CHR19: 42363987 -42375484
Locus: 19q13.2
Gene Diseases
The RPS19 CEACAM5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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