RPS14-AP1G2 Fusion FISH Probe
The RPS14-AP1G2 Fusion FISH Probe is used to confirm a fusion of the RPS14 and AP1G2 genes. The fusion of the RPS14 and AP1G2 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPS14-AP1G2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-RERE | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-REOR | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-REGO | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-REGR | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-REAQ | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-ORRE | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-OROR | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-ORGO | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-GORE | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-GOOR | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-GOGO | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-GOGR | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-GRRE | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-GROR | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-GRGO | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-GRGR | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-AQRE | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-AQOR | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-AQGO | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-AQGR | 20 (40 μL) | 200 μL |
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| RPS14-AP1G2-20-AQAQ | 20 (40 μL) | 200 μL |
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RPS14 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal Protein S14
Chromosome: CHR5: 149823791 -149829319
Locus: 5q33.1
AP1G2 Gene Summary
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. [provided by RefSeq, Aug 2017]
Gene Name: Adaptor Related Protein Complex 1 Gamma 2 Subunit
Chromosome: CHR14: 24028776 -24037279
Locus: 14q11.2
Gene Diseases
The RPS14 AP1G2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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