RPRD1A-CHMP2B Fusion FISH Probe
The RPRD1A-CHMP2B Fusion FISH Probe is used to confirm a fusion of the RPRD1A and CHMP2B genes. The fusion of the RPRD1A and CHMP2B genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPRD1A-CHMP2B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-RERE | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-REOR | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-REGO | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-REGR | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-REAQ | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-ORRE | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-OROR | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-ORGO | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-GORE | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-GOOR | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-GOGO | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-GOGR | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-GRRE | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-GROR | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-GRGO | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-GRGR | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-AQRE | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-AQOR | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-AQGO | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-AQGR | 20 (40 μL) | 200 μL |
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| RPRD1A-CHMP2B-20-AQAQ | 20 (40 μL) | 200 μL |
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CHMP2B Gene Summary
This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]
Gene Name: Charged Multivesicular Body Protein 2B
Chromosome: CHR3: 87276412 -87304698
Locus: 3p11.2
RPRD1A Gene Summary
This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014]
Gene Name: Regulation Of Nuclear Pre-mRNA Domain Containing 1A
Chromosome: CHR18: 33569791 -33647373
Locus: 18q12.2
Gene Diseases
The RPRD1A CHMP2B Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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