RPN1-UTRN Fusion FISH Probe
The RPN1-UTRN Fusion FISH Probe is used to confirm a fusion of the RPN1 and UTRN genes. The fusion of the RPN1 and UTRN genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPN1-UTRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-RERE | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-REOR | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-REGO | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-REGR | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-REAQ | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-ORRE | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-OROR | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-ORGO | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-GORE | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-GOOR | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-GOGO | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-GOGR | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-GRRE | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-GROR | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-GRGO | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-GRGR | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-AQRE | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-AQOR | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-AQGO | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-AQGR | 20 (40 μL) | 200 μL |
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| RPN1-UTRN-20-AQAQ | 20 (40 μL) | 200 μL |
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RPN1 Gene Summary
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]
Gene Name: Ribophorin I
Chromosome: CHR3: 128338812 -128369719
Locus: 3q21.3
UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
Gene Diseases
The RPN1 UTRN Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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