RPL8-SNW1 Fusion FISH Probe
The RPL8-SNW1 Fusion FISH Probe is used to confirm a fusion of the RPL8 and SNW1 genes. The fusion of the RPL8 and SNW1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPL8-SNW1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-RERE | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-REOR | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-REGO | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-REGR | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-REAQ | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-ORRE | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-OROR | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-ORGO | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-GORE | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-GOOR | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-GOGO | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-GOGR | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-GRRE | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-GROR | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-GRGO | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-GRGR | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-AQRE | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-AQOR | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-AQGO | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-AQGR | 20 (40 μL) | 200 μL |
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| RPL8-SNW1-20-AQAQ | 20 (40 μL) | 200 μL |
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RPL8 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal Protein L8
Chromosome: CHR8: 146015153 -146017805
Locus: 8q24.3
SNW1 Gene Summary
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: SNW Domain Containing 1
Chromosome: CHR14: 78183943 -78227497
Locus: 14q24.3
Gene Diseases
The RPL8 SNW1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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