RPL8-NOVA1 Fusion FISH Probe
The RPL8-NOVA1 Fusion FISH Probe is used to confirm a fusion of the RPL8 and NOVA1 genes. The fusion of the RPL8 and NOVA1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPL8-NOVA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-RERE | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-REOR | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-REGO | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-REGR | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-REAQ | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-ORRE | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-OROR | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-ORGO | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-GORE | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-GOOR | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-GOGO | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-GOGR | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-GRRE | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-GROR | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-GRGO | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-GRGR | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-AQRE | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-AQOR | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-AQGO | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-AQGR | 20 (40 μL) | 200 μL |
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| RPL8-NOVA1-20-AQAQ | 20 (40 μL) | 200 μL |
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NOVA1 Gene Summary
This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: NOVA Alternative Splicing Regulator 1
Chromosome: CHR14: 26915088 -27066960
Locus: 14q12
RPL8 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal Protein L8
Chromosome: CHR8: 146015153 -146017805
Locus: 8q24.3
Gene Diseases
The RPL8 NOVA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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