RPL8-CFB Fusion FISH Probe
The RPL8-CFB Fusion FISH Probe is used to confirm a fusion of the RPL8 and CFB genes. The fusion of the RPL8 and CFB genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPL8-CFB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-RERE | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-REOR | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-REGO | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-REGR | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-REAQ | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-ORRE | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-OROR | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-ORGO | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-GORE | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-GOOR | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-GOGO | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-GOGR | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-GRRE | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-GROR | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-GRGO | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-GRGR | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-AQRE | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-AQOR | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-AQGO | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-AQGR | 20 (40 μL) | 200 μL |
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| RPL8-CFB-20-AQAQ | 20 (40 μL) | 200 μL |
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CFB Gene Summary
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
Gene Name: Complement Factor B
Chromosome: CHR6_dbb_hap3: 3199308 -3205449
Locus: 6p21.33
RPL8 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein associates with the 5.8S rRNA, very likely participates in the binding of aminoacyl-tRNA, and is a constituent of the elongation factor 2-binding site at the ribosomal subunit interface. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal Protein L8
Chromosome: CHR8: 146015153 -146017805
Locus: 8q24.3
Gene Diseases
The RPL8 CFB Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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