RPL41-SMARCC2 Fusion FISH Probe
The RPL41-SMARCC2 Fusion FISH Probe is used to confirm a fusion of the RPL41 and SMARCC2 genes. The fusion of the RPL41 and SMARCC2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RPL41-SMARCC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| RPL41-SMARCC2-20-AQAQ | 20 (40 μL) | 200 μL |
|
RPL41 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal Protein L41
Chromosome: CHR12: 56510373 -56511616
Locus: 12q13.2
SMARCC2 Gene Summary
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin Subfamily C Member 2
Chromosome: CHR12: 56555635 -56583351
Locus: 12q13.2
Gene Diseases
The RPL41 SMARCC2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|