RPL22-ACOT7 Fusion FISH Probe
The RPL22-ACOT7 Fusion FISH Probe is used to confirm a fusion of the RPL22 and ACOT7 genes. The fusion of the RPL22 and ACOT7 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPL22-ACOT7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-RERE | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-REOR | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-REGO | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-REGR | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-REAQ | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-ORRE | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-OROR | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-ORGO | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-GORE | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-GOOR | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-GOGO | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-GOGR | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-GRRE | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-GROR | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-GRGO | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-GRGR | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-AQRE | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-AQOR | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-AQGO | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-AQGR | 20 (40 μL) | 200 μL |
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| RPL22-ACOT7-20-AQAQ | 20 (40 μL) | 200 μL |
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RPL22 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]
Gene Name: Ribosomal Protein L22
Chromosome: CHR1: 6245079 -6259679
Locus: 1p36.31
ACOT7 Gene Summary
This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Acyl-CoA Thioesterase 7
Chromosome: CHR1: 6324331 -6453826
Locus: 1p36.31
Gene Diseases
The RPL22 ACOT7 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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