RPL18-AR Fusion FISH Probe
The RPL18-AR Fusion FISH Probe is used to confirm a fusion of the RPL18 and AR genes. The fusion of the RPL18 and AR genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RPL18-AR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-RERE | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-REOR | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-REGO | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-REGR | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-REAQ | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-ORRE | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-OROR | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-ORGO | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-ORAQ | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-GORE | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-GOOR | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-GOGO | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-GOGR | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-GOAQ | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-GRRE | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-GROR | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-GRGO | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-GRGR | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-GRAQ | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-AQRE | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-AQOR | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-AQGO | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-AQGR | 20 (40 μL) | 200 μL |
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| RPL18-AR-20-AQAQ | 20 (40 μL) | 200 μL |
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AR Gene Summary
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Gene Name: Androgen Receptor
Chromosome: CHRX: 66763873 -66944119
Locus: Xq12
RPL18 Gene Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Ribosomal Protein L18
Chromosome: CHR19: 49118587 -49122433
Locus: 19q13.33
Gene Diseases
The RPL18 AR Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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