RORA-PTPN9 Fusion FISH Probe
The RORA-PTPN9 Fusion FISH Probe is used to confirm a fusion of the RORA and PTPN9 genes. The fusion of the RORA and PTPN9 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RORA-PTPN9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-RERE | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-REOR | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-REGO | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-REGR | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-REAQ | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-ORRE | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-OROR | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-ORGO | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-ORAQ | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-GORE | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-GOOR | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-GOGO | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-GOGR | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-GOAQ | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-GRRE | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-GROR | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-GRGO | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-GRGR | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-GRAQ | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-AQRE | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-AQOR | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-AQGO | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-AQGR | 20 (40 μL) | 200 μL |
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| RORA-PTPN9-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPN9 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 9
Chromosome: CHR15: 75759461 -75871625
Locus: 15q24.2
RORA Gene Summary
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]
Gene Name: RAR Related Orphan Receptor A
Chromosome: CHR15: 60780482 -61521502
Locus: 15q22.2
Gene Diseases
The RORA PTPN9 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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