RORA-LOXL1 Fusion FISH Probe
The RORA-LOXL1 Fusion FISH Probe is used to confirm a fusion of the RORA and LOXL1 genes. The fusion of the RORA and LOXL1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RORA-LOXL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-RERE | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-REOR | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-REGO | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-REGR | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-REAQ | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-ORRE | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-OROR | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-ORGO | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-GORE | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-GOOR | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-GOGO | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-GOGR | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-GRRE | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-GROR | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-GRGO | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-GRGR | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-AQRE | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-AQOR | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-AQGO | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-AQGR | 20 (40 μL) | 200 μL |
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| RORA-LOXL1-20-AQAQ | 20 (40 μL) | 200 μL |
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LOXL1 Gene Summary
This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome. [provided by RefSeq, Jan 2016]
Gene Name: Lysyl Oxidase Like 1
Chromosome: CHR15: 74218788 -74244478
Locus: 15q24.1
RORA Gene Summary
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]
Gene Name: RAR Related Orphan Receptor A
Chromosome: CHR15: 60780482 -61521502
Locus: 15q22.2
Gene Diseases
The RORA LOXL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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