ROCK2-ASAP2 Fusion FISH Probe
The ROCK2-ASAP2 Fusion FISH Probe is used to confirm a fusion of the ROCK2 and ASAP2 genes. The fusion of the ROCK2 and ASAP2 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ROCK2-ASAP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-RERE | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-REOR | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-REGO | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-REGR | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-REAQ | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-ORRE | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-OROR | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-ORGO | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-GORE | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-GOOR | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-GOGO | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-GOGR | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-GRRE | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-GROR | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-GRGO | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-GRGR | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-AQRE | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-AQOR | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-AQGO | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-AQGR | 20 (40 μL) | 200 μL |
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| ROCK2-ASAP2-20-AQAQ | 20 (40 μL) | 200 μL |
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ASAP2 Gene Summary
This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Name: ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 2
Chromosome: CHR2: 9346893 -9545812
Locus: 2p24
ROCK2 Gene Summary
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
Gene Name: Rho Associated Coiled-coil Containing Protein Kinase 2
Chromosome: CHR2: 11321777 -11484711
Locus: 2p25.1
Gene Diseases
The ROCK2 ASAP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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