ROCK1-RNF38 Fusion FISH Probe
The ROCK1-RNF38 Fusion FISH Probe is used to confirm a fusion of the ROCK1 and RNF38 genes. The fusion of the ROCK1 and RNF38 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ROCK1-RNF38-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-RERE | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-REOR | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-REGO | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-REGR | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-REAQ | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-ORRE | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-OROR | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-ORGO | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-ORAQ | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-GORE | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-GOOR | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-GOGO | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-GOGR | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-GOAQ | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-GRRE | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-GROR | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-GRGO | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-GRGR | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-GRAQ | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-AQRE | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-AQOR | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-AQGO | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-AQGR | 20 (40 μL) | 200 μL |
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| ROCK1-RNF38-20-AQAQ | 20 (40 μL) | 200 μL |
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ROCK1 Gene Summary
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Gene Name: Rho Associated Coiled-coil Containing Protein Kinase 1
Chromosome: CHR18: 18529702 -18691812
Locus: 18q11.1
RNF38 Gene Summary
This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Name: Ring Finger Protein 38
Chromosome: CHR9: 36336398 -36401195
Locus: 9p13.2
Gene Diseases
The ROCK1 RNF38 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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