ROCK1-OSBPL1A Fusion FISH Probe
The ROCK1-OSBPL1A Fusion FISH Probe is used to confirm a fusion of the ROCK1 and OSBPL1A genes. The fusion of the ROCK1 and OSBPL1A genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ROCK1-OSBPL1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-RERE | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-REOR | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-REGO | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-REGR | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-REAQ | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-ORRE | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-OROR | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-ORGO | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-GORE | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-GOOR | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-GOGO | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-GOGR | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-GRRE | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-GROR | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-GRGO | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-GRGR | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-AQRE | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-AQOR | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-AQGO | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-AQGR | 20 (40 μL) | 200 μL |
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| ROCK1-OSBPL1A-20-AQAQ | 20 (40 μL) | 200 μL |
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ROCK1 Gene Summary
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Gene Name: Rho Associated Coiled-coil Containing Protein Kinase 1
Chromosome: CHR18: 18529702 -18691812
Locus: 18q11.1
OSBPL1A Gene Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Oxysterol Binding Protein Like 1A
Chromosome: CHR18: 21742010 -21977833
Locus: 18q11.2
Gene Diseases
The ROCK1 OSBPL1A Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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