ROCK1-MAP1B Fusion FISH Probe
The ROCK1-MAP1B Fusion FISH Probe is used to confirm a fusion of the ROCK1 and MAP1B genes. The fusion of the ROCK1 and MAP1B genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ROCK1-MAP1B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-RERE | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-REOR | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-REGO | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-REGR | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-REAQ | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-ORRE | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-OROR | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-ORGO | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-ORAQ | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-GORE | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-GOOR | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-GOGO | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-GOGR | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-GOAQ | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-GRRE | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-GROR | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-GRGO | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-GRGR | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-GRAQ | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-AQRE | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-AQOR | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-AQGO | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-AQGR | 20 (40 μL) | 200 μL |
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| ROCK1-MAP1B-20-AQAQ | 20 (40 μL) | 200 μL |
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MAP1B Gene Summary
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [provided by RefSeq, Jul 2008]
Gene Name: Microtubule Associated Protein 1B
Chromosome: CHR5: 71403117 -71505397
Locus: 5q13.2
ROCK1 Gene Summary
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Gene Name: Rho Associated Coiled-coil Containing Protein Kinase 1
Chromosome: CHR18: 18529702 -18691812
Locus: 18q11.1
Gene Diseases
The ROCK1 MAP1B Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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