ROCK1-DCC Fusion FISH Probe
The ROCK1-DCC Fusion FISH Probe is used to confirm a fusion of the ROCK1 and DCC genes. The fusion of the ROCK1 and DCC genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ROCK1-DCC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-RERE | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-REOR | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-REGO | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-REGR | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-REAQ | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-ORRE | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-OROR | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-ORGO | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-ORAQ | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-GORE | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-GOOR | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-GOGO | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-GOGR | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-GOAQ | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-GRRE | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-GROR | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-GRGO | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-GRGR | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-GRAQ | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-AQRE | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-AQOR | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-AQGO | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-AQGR | 20 (40 μL) | 200 μL |
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| ROCK1-DCC-20-AQAQ | 20 (40 μL) | 200 μL |
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DCC Gene Summary
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
Gene Name: DCC Netrin 1 Receptor
Chromosome: CHR18: 49866541 -51062273
Locus: 18q21.2
ROCK1 Gene Summary
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Gene Name: Rho Associated Coiled-coil Containing Protein Kinase 1
Chromosome: CHR18: 18529702 -18691812
Locus: 18q11.1
Gene Diseases
The ROCK1 DCC Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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