ROCK1-CDH2 Fusion FISH Probe
The ROCK1-CDH2 Fusion FISH Probe is used to confirm a fusion of the ROCK1 and CDH2 genes. The fusion of the ROCK1 and CDH2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ROCK1-CDH2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-RERE | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-REOR | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-REGO | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-REGR | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-REAQ | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-ORRE | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-OROR | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-ORGO | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-GORE | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-GOOR | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-GOGO | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-GOGR | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-GRRE | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-GROR | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-GRGO | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-GRGR | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-AQRE | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-AQOR | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-AQGO | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-AQGR | 20 (40 μL) | 200 μL |
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| ROCK1-CDH2-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH2 Gene Summary
This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]
Gene Name: Cadherin 2
Chromosome: CHR18: 25530929 -25757445
Locus: 18q12.1
ROCK1 Gene Summary
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Gene Name: Rho Associated Coiled-coil Containing Protein Kinase 1
Chromosome: CHR18: 18529702 -18691812
Locus: 18q11.1
Gene Diseases
The ROCK1 CDH2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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