ROCK1-CABYR Fusion FISH Probe
The ROCK1-CABYR Fusion FISH Probe is used to confirm a fusion of the ROCK1 and CABYR genes. The fusion of the ROCK1 and CABYR genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ROCK1-CABYR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-RERE | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-REOR | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-REGO | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-REGR | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-OROR | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-GORE | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-GROR | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| ROCK1-CABYR-20-AQAQ | 20 (40 μL) | 200 μL |
|
ROCK1 Gene Summary
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Gene Name: Rho Associated Coiled-coil Containing Protein Kinase 1
Chromosome: CHR18: 18529702 -18691812
Locus: 18q11.1
CABYR Gene Summary
To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Gene Name: Calcium Binding Tyrosine Phosphorylation Regulated
Chromosome: CHR18: 21718954 -21741564
Locus: 18q11.2
Gene Diseases
The ROCK1 CABYR Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|