ROCK1-B4GALT6 Fusion FISH Probe
The ROCK1-B4GALT6 Fusion FISH Probe is used to confirm a fusion of the ROCK1 and B4GALT6 genes. The fusion of the ROCK1 and B4GALT6 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ROCK1-B4GALT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-RERE | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-REOR | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-REGO | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-REGR | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-REAQ | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-ORRE | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-OROR | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-ORGO | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-GORE | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-GOOR | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-GOGO | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-GOGR | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-GRRE | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-GROR | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-GRGO | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-GRGR | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-AQRE | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-AQOR | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-AQGO | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-AQGR | 20 (40 μL) | 200 μL |
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| ROCK1-B4GALT6-20-AQAQ | 20 (40 μL) | 200 μL |
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ROCK1 Gene Summary
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Gene Name: Rho Associated Coiled-coil Containing Protein Kinase 1
Chromosome: CHR18: 18529702 -18691812
Locus: 18q11.1
B4GALT6 Gene Summary
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Jul 2008]
Gene Name: Beta-1,4-galactosyltransferase 6
Chromosome: CHR18: 29202208 -29264686
Locus: 18q12.1
Gene Diseases
The ROCK1 B4GALT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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