ROBO1-SEMA5B Fusion FISH Probe
The ROBO1-SEMA5B Fusion FISH Probe is used to confirm a fusion of the ROBO1 and SEMA5B genes. The fusion of the ROBO1 and SEMA5B genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ROBO1-SEMA5B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-RERE | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-REOR | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-REGO | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-REGR | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-REAQ | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-ORRE | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-OROR | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-ORGO | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-ORAQ | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-GORE | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-GOOR | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-GOGO | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-GOGR | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-GOAQ | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-GRRE | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-GROR | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-GRGO | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-GRGR | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-GRAQ | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-AQRE | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-AQOR | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-AQGO | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-AQGR | 20 (40 μL) | 200 μL |
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| ROBO1-SEMA5B-20-AQAQ | 20 (40 μL) | 200 μL |
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ROBO1 Gene Summary
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Name: Roundabout Guidance Receptor 1
Chromosome: CHR3: 78646387 -79817059
Locus: 3p12.3
SEMA5B Gene Summary
This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Semaphorin 5B
Chromosome: CHR3: 122628042 -122746576
Locus: 3q21.1
Gene Diseases
The ROBO1 SEMA5B Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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