ROBO1-MED12L Fusion FISH Probe
The ROBO1-MED12L Fusion FISH Probe is used to confirm a fusion of the ROBO1 and MED12L genes. The fusion of the ROBO1 and MED12L genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ROBO1-MED12L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-RERE | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-REOR | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-REGO | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-REGR | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-REAQ | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-ORRE | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-OROR | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-ORGO | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-ORAQ | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-GORE | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-GOOR | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-GOGO | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-GOGR | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-GOAQ | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-GRRE | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-GROR | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-GRGO | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-GRGR | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-GRAQ | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-AQRE | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-AQOR | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-AQGO | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-AQGR | 20 (40 μL) | 200 μL |
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| ROBO1-MED12L-20-AQAQ | 20 (40 μL) | 200 μL |
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ROBO1 Gene Summary
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Name: Roundabout Guidance Receptor 1
Chromosome: CHR3: 78646387 -79817059
Locus: 3p12.3
MED12L Gene Summary
The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010]
Gene Name: Mediator Complex Subunit 12 Like
Chromosome: CHR3: 150804675 -151154465
Locus: 3q25.1
Gene Diseases
The ROBO1 MED12L Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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