RNH1-TOLLIP Fusion FISH Probe
The RNH1-TOLLIP Fusion FISH Probe is used to confirm a fusion of the RNH1 and TOLLIP genes. The fusion of the RNH1 and TOLLIP genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNH1-TOLLIP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-RERE | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-REOR | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-REGO | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-REGR | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-REAQ | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-ORRE | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-OROR | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-ORGO | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-GORE | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-GOOR | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-GOGO | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-GOGR | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-GRRE | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-GROR | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-GRGO | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-GRGR | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-AQRE | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-AQOR | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-AQGO | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-AQGR | 20 (40 μL) | 200 μL |
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| RNH1-TOLLIP-20-AQAQ | 20 (40 μL) | 200 μL |
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RNH1 Gene Summary
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
Gene Name: Ribonuclease/angiogenin Inhibitor 1
Chromosome: CHR11: 494511 -507273
Locus: 11p15.5
TOLLIP Gene Summary
This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Gene Name: Toll Interacting Protein
Chromosome: CHR11: 1295597 -1330892
Locus: 11p15.5
Gene Diseases
The RNH1 TOLLIP Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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