RNH1-HRAS Fusion FISH Probe
The RNH1-HRAS Fusion FISH Probe is used to confirm a fusion of the RNH1 and HRAS genes. The fusion of the RNH1 and HRAS genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNH1-HRAS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-RERE | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-REOR | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-REGO | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-REGR | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-REAQ | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-ORRE | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-OROR | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-ORGO | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-GORE | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-GOOR | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-GOGO | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-GOGR | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-GRRE | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-GROR | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-GRGO | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-GRGR | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-AQRE | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-AQOR | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-AQGO | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-AQGR | 20 (40 μL) | 200 μL |
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| RNH1-HRAS-20-AQAQ | 20 (40 μL) | 200 μL |
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HRAS Gene Summary
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: HRas Proto-oncogene, GTPase
Chromosome: CHR11: 532241 -535550
Locus: 11p15.5
RNH1 Gene Summary
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
Gene Name: Ribonuclease/angiogenin Inhibitor 1
Chromosome: CHR11: 494511 -507273
Locus: 11p15.5
Gene Diseases
The RNH1 HRAS Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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