RNH1-DEAF1 Fusion FISH Probe
The RNH1-DEAF1 Fusion FISH Probe is used to confirm a fusion of the RNH1 and DEAF1 genes. The fusion of the RNH1 and DEAF1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNH1-DEAF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-RERE | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-REOR | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-REGO | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-REGR | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-REAQ | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-ORRE | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-OROR | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-ORGO | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-GORE | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-GOOR | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-GOGO | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-GOGR | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-GRRE | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-GROR | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-GRGO | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-GRGR | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-AQRE | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-AQOR | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-AQGO | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-AQGR | 20 (40 μL) | 200 μL |
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| RNH1-DEAF1-20-AQAQ | 20 (40 μL) | 200 μL |
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RNH1 Gene Summary
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
Gene Name: Ribonuclease/angiogenin Inhibitor 1
Chromosome: CHR11: 494511 -507273
Locus: 11p15.5
DEAF1 Gene Summary
This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Name: DEAF1, Transcription Factor
Chromosome: CHR11: 644224 -695740
Locus: 11p15.5
Gene Diseases
The RNH1 DEAF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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