RNH1-COL5A1 Fusion FISH Probe
The RNH1-COL5A1 Fusion FISH Probe is used to confirm a fusion of the RNH1 and COL5A1 genes. The fusion of the RNH1 and COL5A1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNH1-COL5A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-RERE | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-REOR | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-REGO | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-REGR | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-REAQ | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-ORRE | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-OROR | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-ORGO | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-GORE | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-GOOR | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-GOGO | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-GOGR | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-GRRE | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-GROR | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-GRGO | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-GRGR | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-AQRE | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-AQOR | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-AQGO | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-AQGR | 20 (40 μL) | 200 μL |
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| RNH1-COL5A1-20-AQAQ | 20 (40 μL) | 200 μL |
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COL5A1 Gene Summary
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Name: Collagen Type V Alpha 1 Chain
Chromosome: CHR9: 137533651 -137736688
Locus: 9q34.3
RNH1 Gene Summary
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
Gene Name: Ribonuclease/angiogenin Inhibitor 1
Chromosome: CHR11: 494511 -507273
Locus: 11p15.5
Gene Diseases
The RNH1 COL5A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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