RNF43-RARA Fusion FISH Probe
The RNF43-RARA Fusion FISH Probe is used to confirm a fusion of the RNF43 and RARA genes. The fusion of the RNF43 and RARA genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF43-RARA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-RERE | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-REOR | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-REGO | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-REGR | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-OROR | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-GORE | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-GROR | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF43-RARA-20-AQAQ | 20 (40 μL) | 200 μL |
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RARA Gene Summary
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]
Gene Name: Retinoic Acid Receptor Alpha
Chromosome: CHR17: 38465422 -38513895
Locus: 17q21.2
RNF43 Gene Summary
The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Gene Name: Ring Finger Protein 43
Chromosome: CHR17: 56431037 -56494931
Locus: 17q22
Gene Diseases
The RNF43 RARA Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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