RNF40-PLK1 Fusion FISH Probe
The RNF40-PLK1 Fusion FISH Probe is used to confirm a fusion of the RNF40 and PLK1 genes. The fusion of the RNF40 and PLK1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RNF40-PLK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| RNF40-PLK1-20-AQAQ | 20 (40 μL) | 200 μL |
|
PLK1 Gene Summary
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]
Gene Name: Polo Like Kinase 1
Chromosome: CHR16: 23690200 -23701688
Locus: 16p12.2
RNF40 Gene Summary
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Name: Ring Finger Protein 40
Chromosome: CHR16: 30772932 -30787628
Locus: 16p11.2
Gene Diseases
The RNF40 PLK1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|