RNF40-IL21R Fusion FISH Probe
The RNF40-IL21R Fusion FISH Probe is used to confirm a fusion of the RNF40 and IL21R genes. The fusion of the RNF40 and IL21R genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| RNF40-IL21R-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-RERE | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-REOR | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-REGO | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-REGR | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-OROR | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-GORE | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-GROR | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| RNF40-IL21R-20-AQAQ | 20 (40 μL) | 200 μL |
|
RNF40 Gene Summary
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Gene Name: Ring Finger Protein 40
Chromosome: CHR16: 30772932 -30787628
Locus: 16p11.2
IL21R Gene Summary
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
Gene Name: Interleukin 21 Receptor
Chromosome: CHR16: 27413482 -27463363
Locus: 16p12.1
Gene Diseases
The RNF40 IL21R Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|