RNF34-WDFY2 Fusion FISH Probe
The RNF34-WDFY2 Fusion FISH Probe is used to confirm a fusion of the RNF34 and WDFY2 genes. The fusion of the RNF34 and WDFY2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF34-WDFY2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-RERE | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-REOR | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-REGO | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-REGR | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-OROR | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-GORE | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-GROR | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF34-WDFY2-20-AQAQ | 20 (40 μL) | 200 μL |
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RNF34 Gene Summary
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Gene Name: Ring Finger Protein 34
Chromosome: CHR12: 121837901 -121862155
Locus: 12q24.31
WDFY2 Gene Summary
This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]
Gene Name: WD Repeat And FYVE Domain Containing 2
Chromosome: CHR13: 52158483 -52336171
Locus: 13q14.3
Gene Diseases
The RNF34 WDFY2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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