RNF217-RSPO3 Fusion FISH Probe
The RNF217-RSPO3 Fusion FISH Probe is used to confirm a fusion of the RNF217 and RSPO3 genes. The fusion of the RNF217 and RSPO3 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF217-RSPO3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-RERE | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-REOR | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-REGO | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-REGR | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-OROR | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-GORE | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-GROR | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF217-RSPO3-20-AQAQ | 20 (40 μL) | 200 μL |
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RSPO3 Gene Summary
This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013]
Gene Name: R-spondin 3
Chromosome: CHR6: 127440047 -127518184
Locus: 6q22.33
RNF217 Gene Summary
This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Gene Name: Ring Finger Protein 217
Chromosome: CHR6: 125304513 -125404661
Locus: 6q22.31
Gene Diseases
The RNF217 RSPO3 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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