RNF217-PTPRK Fusion FISH Probe
The RNF217-PTPRK Fusion FISH Probe is used to confirm a fusion of the RNF217 and PTPRK genes. The fusion of the RNF217 and PTPRK genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF217-PTPRK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-RERE | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-REOR | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-REGO | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-REGR | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-OROR | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-GORE | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-GROR | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF217-PTPRK-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPRK Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type K
Chromosome: CHR6: 128289923 -128841870
Locus: 6q22.33
RNF217 Gene Summary
This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Gene Name: Ring Finger Protein 217
Chromosome: CHR6: 125304513 -125404661
Locus: 6q22.31
Gene Diseases
The RNF217 PTPRK Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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