RNF217-PRDM1 Fusion FISH Probe
The RNF217-PRDM1 Fusion FISH Probe is used to confirm a fusion of the RNF217 and PRDM1 genes. The fusion of the RNF217 and PRDM1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF217-PRDM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-RERE | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-REOR | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-REGO | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-REGR | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-OROR | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-GORE | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-GROR | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF217-PRDM1-20-AQAQ | 20 (40 μL) | 200 μL |
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PRDM1 Gene Summary
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: PR/SET Domain 1
Chromosome: CHR6: 106534194 -106557814
Locus: 6q21
RNF217 Gene Summary
This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Gene Name: Ring Finger Protein 217
Chromosome: CHR6: 125304513 -125404661
Locus: 6q22.31
Gene Diseases
The RNF217 PRDM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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