RNF216-ST14 Fusion FISH Probe
The RNF216-ST14 Fusion FISH Probe is used to confirm a fusion of the RNF216 and ST14 genes. The fusion of the RNF216 and ST14 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF216-ST14-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-RERE | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-REOR | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-REGO | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-REGR | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-OROR | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-GORE | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-GROR | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF216-ST14-20-AQAQ | 20 (40 μL) | 200 μL |
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ST14 Gene Summary
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]
Gene Name: Suppression Of Tumorigenicity 14
Chromosome: CHR11: 130029681 -130080257
Locus: 11q24.3
RNF216 Gene Summary
This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]
Gene Name: Ring Finger Protein 216
Chromosome: CHR7: 5659671 -5821361
Locus: 7p22.1
Gene Diseases
The RNF216 ST14 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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