RNF213-TBCD Fusion FISH Probe
The RNF213-TBCD Fusion FISH Probe is used to confirm a fusion of the RNF213 and TBCD genes. The fusion of the RNF213 and TBCD genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF213-TBCD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-RERE | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-REOR | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-REGO | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-REGR | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-OROR | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-GORE | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-GROR | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF213-TBCD-20-AQAQ | 20 (40 μL) | 200 μL |
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TBCD Gene Summary
Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
Gene Name: Tubulin Folding Cofactor D
Chromosome: CHR17: 80709939 -80901062
Locus: 17q25.3
RNF213 Gene Summary
This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Gene Name: Ring Finger Protein 213
Chromosome: CHR17: 78234666 -78370086
Locus: 17q25.3
Gene Diseases
The RNF213 TBCD Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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