RNF213-SLC26A11 Fusion FISH Probe
The RNF213-SLC26A11 Fusion FISH Probe is used to confirm a fusion of the RNF213 and SLC26A11 genes. The fusion of the RNF213 and SLC26A11 genes has been associated with Colon Adenocarcinoma, Breast Invasive Carcinoma, Liver Hepatocellular Carcinoma, and Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF213-SLC26A11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-RERE | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-REOR | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-REGO | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-REGR | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-OROR | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-GORE | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-GROR | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF213-SLC26A11-20-AQAQ | 20 (40 μL) | 200 μL |
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RNF213 Gene Summary
This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Gene Name: Ring Finger Protein 213
Chromosome: CHR17: 78234666 -78370086
Locus: 17q25.3
SLC26A11 Gene Summary
This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Gene Name: Solute Carrier Family 26 Member 11
Chromosome: CHR17: 78194199 -78227308
Locus: 17q25.3
Gene Diseases
The RNF213 SLC26A11 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
| Breast Invasive Carcinoma |
| Liver Hepatocellular Carcinoma |
| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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