RNF213-NVL Fusion FISH Probe
The RNF213-NVL Fusion FISH Probe is used to confirm a fusion of the RNF213 and NVL genes. The fusion of the RNF213 and NVL genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF213-NVL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-RERE | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-REOR | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-REGO | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-REGR | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-OROR | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-GORE | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-GROR | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF213-NVL-20-AQAQ | 20 (40 μL) | 200 μL |
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NVL Gene Summary
This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]
Gene Name: Nuclear VCP-like
Chromosome: CHR1: 224415035 -224517891
Locus: 1q42.11
RNF213 Gene Summary
This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Gene Name: Ring Finger Protein 213
Chromosome: CHR17: 78234666 -78370086
Locus: 17q25.3
Gene Diseases
The RNF213 NVL Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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