RNF213-MYH6 Fusion FISH Probe
The RNF213-MYH6 Fusion FISH Probe is used to confirm a fusion of the RNF213 and MYH6 genes. The fusion of the RNF213 and MYH6 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF213-MYH6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-RERE | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-REOR | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-REGO | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-REGR | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-OROR | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-GORE | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-GROR | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF213-MYH6-20-AQAQ | 20 (40 μL) | 200 μL |
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MYH6 Gene Summary
Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located approximately 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3. [provided by RefSeq, Feb 2017]
Gene Name: Myosin Heavy Chain 6
Chromosome: CHR14: 23851198 -23877486
Locus: 14q11.2
RNF213 Gene Summary
This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Gene Name: Ring Finger Protein 213
Chromosome: CHR17: 78234666 -78370086
Locus: 17q25.3
Gene Diseases
The RNF213 MYH6 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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