RNF2-MRC2 Fusion FISH Probe
The RNF2-MRC2 Fusion FISH Probe is used to confirm a fusion of the RNF2 and MRC2 genes. The fusion of the RNF2 and MRC2 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF2-MRC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-RERE | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-REOR | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-REGO | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-REGR | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-OROR | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-GORE | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-GROR | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF2-MRC2-20-AQAQ | 20 (40 μL) | 200 μL |
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RNF2 Gene Summary
Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008]
Gene Name: Ring Finger Protein 2
Chromosome: CHR1: 185014550 -185071740
Locus: 1q25.3
MRC2 Gene Summary
This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
Gene Name: Mannose Receptor C Type 2
Chromosome: CHR17: 60704761 -60770952
Locus: 17q23.2
Gene Diseases
The RNF2 MRC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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