RNF19A-NCALD Fusion FISH Probe
The RNF19A-NCALD Fusion FISH Probe is used to confirm a fusion of the RNF19A and NCALD genes. The fusion of the RNF19A and NCALD genes has been associated with Bladder Urothelial Carcinoma, and Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF19A-NCALD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-RERE | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-REOR | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-REGO | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-REGR | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-OROR | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-GORE | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-GROR | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF19A-NCALD-20-AQAQ | 20 (40 μL) | 200 μL |
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RNF19A Gene Summary
This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase
Chromosome: CHR8: 101269287 -101322327
Locus: 8q22.2
NCALD Gene Summary
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Neurocalcin Delta
Chromosome: CHR8: 102698769 -103137135
Locus: 8q22.3
Gene Diseases
The RNF19A NCALD Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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