RNF19A-F10 Fusion FISH Probe
The RNF19A-F10 Fusion FISH Probe is used to confirm a fusion of the RNF19A and F10 genes. The fusion of the RNF19A and F10 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF19A-F10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-RERE | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-REOR | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-REGO | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-REGR | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-OROR | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-GORE | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-GROR | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF19A-F10-20-AQAQ | 20 (40 μL) | 200 μL |
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F10 Gene Summary
This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]
Gene Name: Coagulation Factor X
Chromosome: CHR13: 113777112 -113803843
Locus: 13q34
RNF19A Gene Summary
This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase
Chromosome: CHR8: 101269287 -101322327
Locus: 8q22.2
Gene Diseases
The RNF19A F10 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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