RNF170-SFRP1 Fusion FISH Probe
The RNF170-SFRP1 Fusion FISH Probe is used to confirm a fusion of the RNF170 and SFRP1 genes. The fusion of the RNF170 and SFRP1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF170-SFRP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-RERE | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-REOR | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-REGO | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-REGR | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-OROR | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-GORE | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-GROR | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF170-SFRP1-20-AQAQ | 20 (40 μL) | 200 μL |
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SFRP1 Gene Summary
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
Gene Name: Secreted Frizzled Related Protein 1
Chromosome: CHR8: 41119475 -41166990
Locus: 8p11.21
RNF170 Gene Summary
This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Name: Ring Finger Protein 170
Chromosome: CHR8: 42704779 -42751866
Locus: 8p11.21
Gene Diseases
The RNF170 SFRP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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