RNF170-CRYBB1 Fusion FISH Probe
The RNF170-CRYBB1 Fusion FISH Probe is used to confirm a fusion of the RNF170 and CRYBB1 genes. The fusion of the RNF170 and CRYBB1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF170-CRYBB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-RERE | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-REOR | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-REGO | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-REGR | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-OROR | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-GORE | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-GROR | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF170-CRYBB1-20-AQAQ | 20 (40 μL) | 200 μL |
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CRYBB1 Gene Summary
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, undergoes extensive cleavage at its N-terminal extension during lens maturation. It is also a member of a gene cluster with beta-A4, beta-B2, and beta-B3. [provided by RefSeq, Jul 2008]
Gene Name: Crystallin Beta B1
Chromosome: CHR22: 26995361 -27013991
Locus: 22q12.1
RNF170 Gene Summary
This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Name: Ring Finger Protein 170
Chromosome: CHR8: 42704779 -42751866
Locus: 8p11.21
Gene Diseases
The RNF170 CRYBB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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