RNF170-ADAM32 Fusion FISH Probe
The RNF170-ADAM32 Fusion FISH Probe is used to confirm a fusion of the RNF170 and ADAM32 genes. The fusion of the RNF170 and ADAM32 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF170-ADAM32-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-RERE | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-REOR | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-REGO | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-REGR | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-OROR | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-GORE | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-GROR | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF170-ADAM32-20-AQAQ | 20 (40 μL) | 200 μL |
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RNF170 Gene Summary
This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
Gene Name: Ring Finger Protein 170
Chromosome: CHR8: 42704779 -42751866
Locus: 8p11.21
ADAM32 Gene Summary
This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Gene Name: ADAM Metallopeptidase Domain 32
Chromosome: CHR8: 38965049 -39142436
Locus: 8p11.22
Gene Diseases
The RNF170 ADAM32 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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