RNF145-PDE4D Fusion FISH Probe
The RNF145-PDE4D Fusion FISH Probe is used to confirm a fusion of the RNF145 and PDE4D genes. The fusion of the RNF145 and PDE4D genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF145-PDE4D-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-RERE | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-REOR | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-REGO | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-REGR | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-OROR | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-GORE | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-GROR | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF145-PDE4D-20-AQAQ | 20 (40 μL) | 200 μL |
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PDE4D Gene Summary
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Gene Name: Phosphodiesterase 4D
Chromosome: CHR5: 58264865 -59783925
Locus: 5q11.2-q12.1
RNF145 Gene Summary
The Ring Finger Protein 145 (RNF145) gene is located on chr5 :158584416-158637061 at 5q33.3.
Gene Name: Ring Finger Protein 145
Chromosome: CHR5: 158584416 -158637061
Locus: 5q33.3
Gene Diseases
The RNF145 PDE4D Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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