RNF144A-MSH2 Fusion FISH Probe
The RNF144A-MSH2 Fusion FISH Probe is used to confirm a fusion of the RNF144A and MSH2 genes. The fusion of the RNF144A and MSH2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF144A-MSH2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-RERE | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-REOR | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-REGO | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-REGR | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-OROR | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-GORE | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-GROR | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF144A-MSH2-20-AQAQ | 20 (40 μL) | 200 μL |
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MSH2 Gene Summary
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Name: MutS Homolog 2
Chromosome: CHR2: 47630262 -47710360
Locus: 2p21-p16.3
RNF144A Gene Summary
This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Mar 2017]
Gene Name: Ring Finger Protein 144A
Chromosome: CHR2: 7057522 -7184309
Locus: 2p25.1
Gene Diseases
The RNF144A MSH2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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