RNF139-EIF2A Fusion FISH Probe
The RNF139-EIF2A Fusion FISH Probe is used to confirm a fusion of the RNF139 and EIF2A genes. The fusion of the RNF139 and EIF2A genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF139-EIF2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-RERE | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-REOR | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-REGO | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-REGR | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-OROR | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-GORE | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-GROR | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF139-EIF2A-20-AQAQ | 20 (40 μL) | 200 μL |
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RNF139 Gene Summary
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
Gene Name: Ring Finger Protein 139
Chromosome: CHR8: 125487007 -125500859
Locus: 8q24.13
EIF2A Gene Summary
This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Gene Name: Eukaryotic Translation Initiation Factor 2A
Chromosome: CHR3: 150264573 -150303803
Locus: 3q25.1
Gene Diseases
The RNF139 EIF2A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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