RNF121-SF1 Fusion FISH Probe
The RNF121-SF1 Fusion FISH Probe is used to confirm a fusion of the RNF121 and SF1 genes. The fusion of the RNF121 and SF1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF121-SF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-RERE | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-REOR | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-REGO | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-REGR | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-OROR | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-GORE | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-GROR | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF121-SF1-20-AQAQ | 20 (40 μL) | 200 μL |
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SF1 Gene Summary
This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Gene Name: Splicing Factor 1
Chromosome: CHR11: 64532075 -64546316
Locus: 11q13.1
RNF121 Gene Summary
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products. [provided by RefSeq, Sep 2008]
Gene Name: Ring Finger Protein 121
Chromosome: CHR11: 71639767 -71708643
Locus: 11q13.4
Gene Diseases
The RNF121 SF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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