RNF121-MRPL21 Fusion FISH Probe
The RNF121-MRPL21 Fusion FISH Probe is used to confirm a fusion of the RNF121 and MRPL21 genes. The fusion of the RNF121 and MRPL21 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF121-MRPL21-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-RERE | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-REOR | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-REGO | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-REGR | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-OROR | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-GORE | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-GROR | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF121-MRPL21-20-AQAQ | 20 (40 μL) | 200 μL |
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RNF121 Gene Summary
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products. [provided by RefSeq, Sep 2008]
Gene Name: Ring Finger Protein 121
Chromosome: CHR11: 71639767 -71708643
Locus: 11q13.4
MRPL21 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein L21
Chromosome: CHR11: 68658745 -68671303
Locus: 11q13.3
Gene Diseases
The RNF121 MRPL21 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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