RNF111-TCF12 Fusion FISH Probe
The RNF111-TCF12 Fusion FISH Probe is used to confirm a fusion of the RNF111 and TCF12 genes. The fusion of the RNF111 and TCF12 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| RNF111-TCF12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-RERE | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-REOR | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-REGO | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-REGR | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-REAQ | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-ORRE | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-OROR | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-ORGO | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-ORAQ | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-GORE | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-GOOR | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-GOGO | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-GOGR | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-GOAQ | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-GRRE | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-GROR | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-GRGO | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-GRGR | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-GRAQ | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-AQRE | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-AQOR | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-AQGO | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-AQGR | 20 (40 μL) | 200 μL |
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| RNF111-TCF12-20-AQAQ | 20 (40 μL) | 200 μL |
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TCF12 Gene Summary
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Transcription Factor 12
Chromosome: CHR15: 57210832 -57580714
Locus: 15q21.3
RNF111 Gene Summary
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Gene Name: Ring Finger Protein 111
Chromosome: CHR15: 59279864 -59389253
Locus: 15q22.1-q22.2
Gene Diseases
The RNF111 TCF12 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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